A Novel Long Noncoding RNA lincRNA00892 Activates CD4⁺ T Cells in Systemic Lupus Erythematosus by Regulating CD40L.

ABSTRACT: Objective: The mechanism of CD4⁺ T-cell dysfunction in systemic lupus erythematosus (SLE) has not been fully understood. Increasing evidence show that long noncoding RNAs (lncRNAs) can regulate immune responses and take part in some autoimmune diseases, while little is known about the lncRNA expression and function in CD4⁺ T of SLE. Here, we aimed to detect the expression profile of lncRNAs in lupus CD4⁺ T cells and explore the mechanism that how lincRNA00892 in CD4⁺ T cells is involved in the pathogenesis of SLE. Methods: The expression profiles of lncRNAs and mRNAs in CD4⁺ T cells from SLE patients and healthy controls were detected by microarray. LincRNA00892 and CD40L were chosen for validation by quantitative real-ti

SUBMITTER: Liu X 

PROVIDER: S-EPMC8543062 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature