CD3⁺CD4⁺gp130⁺ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients.

ABSTRACT: The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2 and gp130 in CD3⁺CD4⁺, CD3⁺CD4^─ and CD3^─CD4^─ lymphocyte subpopulations in systemic lupus erythematosus (SLE) patients (n=50) versus healthy controls (n=50). The potential T cell subsets associated with gp130 transcript (i.e. IL6ST) expression in CD4⁺ T cells of SLE patients was also examined in publicly-available gene expression profiling (GEP) datasets. Here, we report that serum IL-35 levels were significantly higher in SLE patients than healthy controls (p=0.038) but it was no

SUBMITTER: Mohd Shukri ND 

PROVIDER: S-EPMC8213373 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature