Screening and validation of a novel T stage-lymph node ratio classification for operable colon cancer.

ABSTRACT:

Background

Lymph node ratio (LNR) has advantages in predicting prognosis compared with American Joint Committee on Cancer (AJCC) pathological N stage. However, the prognostic value of a novel T stage-lymph node ratio (TLNR) classification for colon cancer combining LNR and pathological primary tumor stage (T stage) is currently unknown.

Methods

We included 62,294 patients with stage I-III colon cancer from the Surveillance, Epidemiology, and End Results Program as a training cohort. External validation was performed in 3,327 additional patients. A novel LNR stage was established and combined with T stage in a novel TLNR classification. Patients with similar survival were grouped according to T and LNR stages, with T1LNR1 as a reference.

Results

We developed a novel TL

SUBMITTER: Pei JP 

PROVIDER: S-EPMC8576719 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature