Causal associations between COVID-19 and atrial fibrillation: A bidirectional Mendelian randomization study.

ABSTRACT:

Background and aims

Observational studies showed that coronavirus disease (2019) (COVID-19) attacks universally and its most menacing progression uniquely endangers the elderly with cardiovascular disease (CVD). The causal association between COVID-19 infection or its severity and susceptibility of atrial fibrillation (AF) remains unknown.

Methods and results

The bidirectional causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with not hospitalized COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and AF are determined by using two-sample Mendelian randomization (MR) analysis. Genetically predicted severe COVID-19 was not significantly associated with the risk of AF [odds ratio (OR), 1.037; 95% co

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8605875 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature