Causal associations between obstructive sleep apnea and COVID-19: A bidirectional Mendelian randomization study.

ABSTRACT:

Backgrounds

The COVID-19 pandemic has caused significant impact on human health. Whether obstructive sleep apnea (OSA) increases the risk of COVID-19 remains unclear. We sought to clarify this issue using two-sample Mendelian randomization (TSMR) analysis in large cohorts.

Methods

Bidirectional two-sample Mendelian randomization (MR) was used to evaluate the potential causality between OSA and COVID-19 by selecting single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) from genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was selected as the main approach for data analysis to estimate the possible causal effects. Alternative methods such as MR-Egger, the MR pleiotropy residual sum and outlier (MR-PRESSO), and leave-one-out an

SUBMITTER: Gao X 

PROVIDER: S-EPMC9557138 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature