Cell proliferation detected using [¹⁸F]FLT PET/CT as an early marker of abdominal aortic aneurysm.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a focal aortic dilatation progressing towards rupture. Non-invasive AAA-associated cell proliferation biomarkers are not yet established. We investigated the feasibility of the cell proliferation radiotracer, fluorine-18-fluorothymidine ([¹⁸F]FLT) with positron emission tomography/computed tomography (PET/CT) in a progressive pre-clinical AAA model (angiotensin II, AngII infusion).

Methods and results

Fourteen-week-old apolipoprotein E-knockout (ApoE^-/-) mice received saline or AngII via osmotic mini-pumps for 14 (n = 7 and 5, respectively) or 28 (n = 3 and 4, respectively) days and underwent 90-minute dynamic [¹⁸F]FLT PET/CT. Organs were harvested from independent cohorts for gamma counting, ultr

SUBMITTER: Gandhi R 

PROVIDER: S-EPMC8648642 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature