Dataset Information

Assessment of different quantification metrics of [¹⁸F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

ABSTRACT:

Background

We aim to assess the spill-in effect and the benefit in quantitative accuracy for [¹⁸F]-NaF PET/CT imaging of abdominal aortic aneurysms (AAA) using the background correction (BC) technique.

Methods

Seventy-two datasets of patients diagnosed with AAA were reconstructed with ordered subset expectation maximization algorithm incorporating point spread function (PSF). Spill-in effect was investigated for the entire aneurysm (AAA), and part of the aneurysm excluding the region close to the bone (AAA_exc). Quantifications of PSF and PSF+BC images using different thresholds (% of max. SUV in target regions-of-interest) to derive target-to-background (TBR) values (TBR_max, TBR₉₀, TBR₇₀ and TBR₅₀) were compared at 3 and 10 iterations.

Results

TBR differences were observed between AAA and AAA_exc due to spill-in effect from the bone into the aneurysm. TBR_max showed the highest sensitivity to the spill-in effect while TBR₅₀ showed the least. The spill-in effect was reduced at 10 iterations compared to 3 iterations, but at the expense of reduced contrast-to-noise ratio (CNR). TBR₅₀ yielded the best trade-off between increased CNR and reduced spill-in effect. PSF+BC method reduced TBR sensitivity to spill-in effect, especially at 3 iterations, compared to PSF (P-value ≤ 0.05).

Conclusion

TBR₅₀ is robust metric for reduced spill-in and increased CNR.

SUBMITTER: Akerele MI

PROVIDER: S-EPMC8873073 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Publications

Assessment of different quantification metrics of [<sup>18</sup>F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

Akerele Mercy I MI Mushari Nouf A NA Forsythe Rachael O RO Syed Maaz M Karakatsanis Nicolas A NA Newby David E DE Dweck Marc R MR Tsoumpas Charalampos C

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20200617 1

<h4>Background</h4>We aim to assess the spill-in effect and the benefit in quantitative accuracy for [<sup>18</sup>F]-NaF PET/CT imaging of abdominal aortic aneurysms (AAA) using the background correction (BC) technique.<h4>Methods</h4>Seventy-two datasets of patients diagnosed with AAA were reconstructed with ordered subset expectation maximization algorithm incorporating point spread function (PSF). Spill-in effect was investigated for the entire aneurysm (AAA), and part of the aneurysm exclud ...[more]

PMID: 32557152

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Dataset Information

Assessment of different quantification metrics of [¹⁸F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

Background

Methods

Results

Conclusion

Publications

Assessment of different quantification metrics of [<sup>18</sup>F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Assessment of different quantification metrics of [18F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

Background

Methods

Results

Conclusion

Publications

Assessment of different quantification metrics of [&lt;sup&gt;18&lt;/sup&gt;F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Assessment of different quantification metrics of [¹⁸F]-NaF PET/CT images of patients with abdominal aortic aneurysm.

Assessment of different quantification metrics of [<sup>18</sup>F]-NaF PET/CT images of patients with abdominal aortic aneurysm.