Imaging coronary plaques using 3D motion-compensated [¹⁸F]NaF PET/MR.

ABSTRACT:

Background

Cardiac PET has recently found novel applications in coronary atherosclerosis imaging using [¹⁸F]NaF as a radiotracer, highlighting vulnerable plaques. However, the resulting uptakes are relatively small, and cardiac motion and respiration-induced movement of the heart can impair the reconstructed images due to motion blurring and attenuation correction mismatches. This study aimed to apply an MR-based motion compensation framework to [¹⁸F]NaF data yielding high-resolution motion-compensated PET and MR images.

Methods

Free-breathing 3-dimensional Dixon MR data were acquired, retrospectively binned into multiple respiratory and cardiac motion states, and split into fat and water fraction using a model-based reconstruction framework. From the d

SUBMITTER: Mayer J 

PROVIDER: S-EPMC8241750 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature