Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24.

ABSTRACT:

Background

We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans and 3 SNPs from 8q24 shown to improve model performance in Africans. Herein, we used principal component (PC) analysis to uncover subpopulations of men with African ancestry for whom the utility of PHS46+African may differ.

Materials and methods

Genotypic data were obtained from the PRACTICAL consortium for 6253 men with African genetic ancestry. Genetic variation in a window spanning 3 African-specific 8q24 SNPs was estimated using 93 PCs. A Cox proportional hazards framework was used to identify the pair of PCs most strongly a

SUBMITTER: Karunamuni RA 

PROVIDER: S-EPMC8669040 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature