Effect of 26 Weeks of Liraglutide Treatment on Coronary Artery Inflammation in Type 2 Diabetes Quantified by [⁶⁴Cu]Cu-DOTATATE PET/CT: Results from the LIRAFLAME Trial.

ABSTRACT:

Background

Quantification of coronary artery inflammation and atherosclerosis remains a challenge in high-risk individuals. In this study we sought to investigate if the glucagon like peptide-1 receptor agonist liraglutide has a direct anti-inflammatory effect in the coronary arteries using positron emission tomography (PET) with a radioactive tracer targeting activated macrophages in the vessel-wall.

Methods

Thirty randomly selected participants with type 2 diabetes from the placebo-controlled trial LIRAFLAME were enrolled in this sub-study. Participants were, prior to enrollment in this sub-study, randomized to either treatment with daily liraglutide (n=15) or placebo (n=15). Both groups underwent a combined [⁶⁴Cu]Cu-DOTATATE positron emission tomography and com

SUBMITTER: Jensen JK 

PROVIDER: S-EPMC8669791 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature