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Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study.


ABSTRACT:

Primary objective

We hypothesized that, in patients with acute severe traumatic brain injury (TBI) who recover basic language function, speech-evoked blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) responses within the canonical language network increase over the first 6 months post-injury.

Research design

We conducted a prospective, longitudinal fMRI pilot study of adults with acute severe TBI admitted to the intensive care unit. We also enrolled age- and sex-matched healthy subjects.

Methods and procedures

We evaluated BOLD signal in bilateral superior temporal gyrus (STG) and inferior frontal gyrus (IFG) regions of interest acutely and approximately 6 months post-injury. Given evidence that regions outside the canonical language network contribute to language processing, we also performed exploratory whole-brain analyses.

Main outcomes and results

Of the 16 patients enrolled, eight returned for follow-up fMRI, all of whom recovered basic language function. We observed speech-evoked longitudinal BOLD increases in the left STG, but not in the right STG, right IFG, or left IFG. Whole-brain analysis revealed increases in the right supramarginal and middle temporal gyri but no differences between patients and healthy subjects (n = 16).

Conclusion

This pilot study suggests that, in patients with severe TBI who recover llanguage function, speech-evoked responses in bihemispheric language-processing cortex reemerge by 6 months post-injury.

SUBMITTER: Coffey BJ 

PROVIDER: S-EPMC8678186 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study.

Coffey Brian J BJ   Threlkeld Zachary D ZD   Foulkes Andrea S AS   Bodien Yelena G YG   Edlow Brian L BL  

Brain injury 20210921 12-13


<h4>Primary objective</h4>We hypothesized that, in patients with acute severe traumatic brain injury (TBI) who recover basic language function, speech-evoked blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) responses within the canonical language network increase over the first 6 months post-injury.<h4>Research design</h4>We conducted a prospective, longitudinal fMRI pilot study of adults with acute severe TBI admitted to the intensive care unit. We also enrolled age- and sex-matched he  ...[more]

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