Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study.

ABSTRACT:

Primary objective

We hypothesized that, in patients with acute severe traumatic brain injury (TBI) who recover basic language function, speech-evoked blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) responses within the canonical language network increase over the first 6 months post-injury.

Research design

We conducted a prospective, longitudinal fMRI pilot study of adults with acute severe TBI admitted to the intensive care unit. We also enrolled age- and sex-matched healthy subjects.

Methods and procedures

We evaluated BOLD signal in bilateral superior temporal gyrus (STG) and inferior frontal gyrus (IFG) regions of interest acutely and approximately 6 months post-injury. Given evidence that regions outside the canonical language network contribute to lang

SUBMITTER: Coffey BJ 

PROVIDER: S-EPMC8678186 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature