Dataset Information

Polymorphism in the TP63 gene imparts a potential risk for leukemia in the North Indian population.

ABSTRACT:

Background

The role of single nucleotide polymorphism rs10937405 (C>T) of the TP63 gene in cancer including leukemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown.

Objectives

In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population.

Methods

A total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay.

Results

A statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51-2.48), p=1.2x10-6].

Conclusion

The current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations.

SUBMITTER: Bhat A

PROVIDER: S-EPMC8843251 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Polymorphism in the <i>TP63</i> gene imparts a potential risk for leukemia in the North Indian population.

Bhat Amrita A Bhat Gh Rasool GR Verma Sonali S Shah Ruchi R Nagpal Ashna A Sharma Bhanu B Bakshi Divya D Suri Jyotsna J Singh Supinder S Tanwar Mukesh M Vaishnavi Samantha S Bhat Audesh A Kumar Rakesh R

African health sciences 20210901 3

<h4>Background</h4>The role of single nucleotide polymorphism rs10937405 (C>T) of the <i>TP63</i> gene in cancer including leukemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown.<h4>Objectives</h4>In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population.<h4>Methods</h4>A total of 588 subjects, ...[more]

PMID: 35222588

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