PM_2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study.

ABSTRACT: Recent studies have shown that PM_2.5 may activate the hypothalamus-pituitary-adrenal (HPA) axis by inducing hormonal changes, potentially explaining the increase in neurological and cardiovascular risks. In addition, an association between PM_2.5 and gut microbiota and metabolites was established. The above evidence represents crucial parts of the gut-brain axis (GBA). In view of this evidence, we proposed a hypothesis that PM_2.5 exposure may affect the HPA axis through the gastrointestinal tract microbiota pathway (GBA mechanism), leading to an increased risk of neurological and cardiovascular diseases. We conducted a real-world prospective repeated panel study in Jinan, China. At each visit, we measured real-time personal PM_2.5 and collected fec

SUBMITTER: Li T 

PROVIDER: S-EPMC8866089 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature