Dataset Information

PM_2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study.

ABSTRACT: Recent studies have shown that PM_2.5 may activate the hypothalamus-pituitary-adrenal (HPA) axis by inducing hormonal changes, potentially explaining the increase in neurological and cardiovascular risks. In addition, an association between PM_2.5 and gut microbiota and metabolites was established. The above evidence represents crucial parts of the gut-brain axis (GBA). In view of this evidence, we proposed a hypothesis that PM_2.5 exposure may affect the HPA axis through the gastrointestinal tract microbiota pathway (GBA mechanism), leading to an increased risk of neurological and cardiovascular diseases. We conducted a real-world prospective repeated panel study in Jinan, China. At each visit, we measured real-time personal PM_2.5 and collected fecal and blood samples. A linear mixed-effects model was used to analyze the association between PM_2.5 and serum biomarkers, gut microbiota, and metabolites. We found that PM_2.5 was associated with increased serum levels of hormones, especially the adrenocorticotropic hormone (ACTH) and cortisol, which are reliable hormones of the HPA axis. Gut microbiota and tryptophan metabolites and inflammation, which are important components of the GBA, were significantly associated with PM_2.5. We also found links between PM_2.5 and changes in the nervous and cardiovascular outcomes, e.g., increases of 19.77% (95% CI: -36.44, 125.69) in anxiety, 1.19% (95% CI: 0.65, 1.74) in fasting blood glucose (FBG), 2.09% (95% CI: 1.48, 2.70) in total cholesterol (TCHOL), and 0.93% (95% CI: 0.14, 1.72) in triglycerides (TG), were associated with 10 μg/m³ increase in PM_2.5 at the lag 0-72 h, which represent the main effects of GBA. This study indicated the link between PM_2.5 and the microbiota GBA for the first time, providing evidence of the potential mechanism for PM_2.5 with neurological and cardiovascular system dysfunction.

SUBMITTER: Li T

PROVIDER: S-EPMC8866089 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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PM2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study.

Li Tiantian T Fang Jianlong J Tang Song S Du Hang H Zhao Liang L Wang Yanwen Y Deng Fuchang F Liu Yuanyuan Y Du Yanjun Y Cui Liangliang L Shi Wanying W Wang Yan Y Wang Jiaonan J Zhang Yingjian Y Dong Xiaoyan X Gao Ying Y Shen Yu Y Dong Li L Zhou Huichan H Sun Qinghua Q Dong Haoran H Peng Xiumiao X Zhang Yi Y Cao Meng M Zhi Hong H Zhou Jingyang J Shi Xiaoming X

Innovation (Cambridge (Mass.)) 20220203 2

Recent studies have shown that PM2.5 may activate the hypothalamus-pituitary-adrenal (HPA) axis by inducing hormonal changes, potentially explaining the increase in neurological and cardiovascular risks. In addition, an association between PM2.5 and gut microbiota and metabolites was established. The above evidence represents crucial parts of the gut-brain axis (GBA). In view of this evidence, we proposed a hypothesis that PM2.5 exposure may affect the HPA axis t ...[more]

PMID: 35243467

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Project description:IntroductionDespite the London Underground (LU) handling on average 2.8 million passenger journeys per day, the characteristics and potential health effects of the elevated concentrations of metal-rich PM2.5 found in this subway system are not well understood.MethodsSpatial monitoring campaigns were carried out to characterise the health-relevant chemical and physical properties of PM2.5 across the LU network, including diurnal and day-to-day variability and spatial distribution (above ground, depth below ground and subway line). Population-weighted station PM2.5 rankings were produced to understand the relative importance of concentrations at different stations and on different lines.ResultsThe PM2.5 mass in the LU (mean 88 μg m-3, median 28 μg m-3) was greater than at ambient background locations (mean 19 μg m-3, median 14 μg m-3) and roadside environments in central London (mean 22 μg m-3, median 14 μg m-3). Concentrations varied between lines and locations, with the deepest and shallowest submerged lines being the District (median 4 μg m-3) and Victoria (median 361 μg m-3 but up to 885 μg m-3). Broadly in agreement with other subway systems around the world, sampled LU PM2.5 comprised 47% iron oxide, 7% elemental carbon, 11% organic carbon, and 14% metallic and mineral oxides. Although a relationship between line depth and air quality inside the tube trains was evident, there were clear influences relating to the distance from cleaner outside air and the exchange with cabin air when the doors open. The passenger population-weighted exposure analysis demonstrated a method to identify stations that should be prioritised for remediation to improve air quality.ConclusionPM2.5 concentrations in the LU are many times higher than in other London transport Environments. Failure to include this environment in epidemiological studies of the relationship between PM2.5 and health in London is therefore likely to lead to a large exposure misclassification error. Given the significant contribution of underground PM2.5 to daily exposure, and the differences in composition compared to urban PM2.5, there is a clear need for well-designed studies to better understand the health effects of underground exposure.

Dataset Information

PM_2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study.

Publications

PM<sub>2.5</sub> exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study.

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