Rich-Club Organization Disturbances of the Individual Morphological Network in Subjective Cognitive Decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) was considered to be the preclinical stage of Alzheimer's disease (AD). However, less is known about the altered rich-club organizations of the morphological networks in individuals with SCD.

Methods

This study included 53 individuals with SCD and 54 well-matched healthy controls (HC) from the Alzheimer's disease Neuroimaging Initiative (ADNI) database. Individual-level brain morphological networks were constructed by estimating the Jensen-Shannon distance-based similarity in the distribution of regional gray matter volume. Rich-club properties were then detected, followed by statistical comparison.

Results

The characteristic rich-club organization of morphological networks (normalized rich-club coefficients > 1) was obser

SUBMITTER: Peng L 

PROVIDER: S-EPMC8914315 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature