Acute restraint stress redirects prefrontal cortex circuit function through mGlu₅ receptor plasticity on somatostatin-expressing interneurons.

ABSTRACT: Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited understanding of the molecular and experience-dependent mechanisms that regulate synaptic plasticity across PFC microcircuits. We discovered that mGlu₅ receptor activation facilitates long-term potentiation at synapses from the basolateral amygdala (BLA) onto somatostatin-expressing interneurons (SST-INs) in mice. This plasticity appeared to be recruited during acute restraint stress, which induced intracellular calcium mobilization within SST-INs and rapidly potentiated postsynaptic strength onto SST-INs. Restraint stress and mGlu₅ receptor activation each augmented BLA recruitment of SST-IN phasic feedforward inhibition, shunting information from other excitatory inputs, incl

SUBMITTER: Joffe ME 

PROVIDER: S-EPMC8930582 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature