SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

It is of obvious interest to identify clinical prognosis-related oncogenes in HNSCC (head and neck squamous cell carcinoma).

Methods

Based on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches.

Results

There was a higher expression level of SEC61G in primary HNSCC tumor tissues than in normal tissues. Moreover, highly expressed SEC61G was statistically associated with the poor survival prognosis of HNSCC patients. When HPV (human papilloma virus) was considered, we also observed a relatively lower proportion of "arm-level gain" and "high ampl

SUBMITTER: Shi Y 

PROVIDER: S-EPMC8930941 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature