Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic markers could help tailor prevention efforts to those at the highest risk. The aim of this study was to identify predictive methylation markers for incident type 2 diabetes by combining epigenome-wide association study (EWAS) results from five prospective European cohorts.

Methods

We conducted a meta-analysis of EWASs in blood collected 7-10 years prior to type 2 diabetes diagnosis. DNA methylation was measured with Illumina Infinium Methylation arrays. A total of 1250 cases and 1950 controls from five longitudinal cohorts were included: Doetinchem, ESTHER, KORA1, KORA2 and EPIC-Norfolk. Associations betwee

SUBMITTER: Fraszczyk E 

PROVIDER: S-EPMC8960572 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature