High relaxivity Gd³⁺-based organic nanoparticles for efficient magnetic resonance angiography.

ABSTRACT: Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T₁-weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for Gd³⁺ coordination to improve the relaxivity and avoid leakage of the Gd³⁺ ions. The synthesized GPT NPs exhibit a high relaxa

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8973627 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature