Electrochemically driven cross-electrophile coupling of alkyl halides.

ABSTRACT: Recent research in medicinal chemistry has suggested that there is a correlation between an increase in the fraction of sp³ carbons-those bonded to four other atoms-in drug candidates and their improved success rate in clinical trials¹. As such, the development of robust and selective methods for the construction of carbon(sp³)-carbon(sp³) bonds remains a critical problem in modern organic chemistry². Owing to the broad availability of alkyl halides, their direct cross-coupling-commonly known as cross-electrophile coupling-provides a promising route towards this objective^3-5. Such transformations circumvent the preparation of carbon nucleophiles used in traditional cross-coupling reactions, as well as stability and functiona

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9016776 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature