Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study.

ABSTRACT:

Background

Risk genes linked to the development of gout have been identified, and lifestyle factors are related to gout risk. It remains unclear whether healthy lifestyle factors can mitigate the genetic risk of gout. Therefore, we aimed to explore whether and to what extent a healthy lifestyle can mitigate the risk of gout related to genetic factors.

Methods

Within the UK Biobank, 416,481 gout-free participants (aged 37-74) were identified at baseline. Polygenic risk for gout was assessed and categorized as low (lowest tertile), middle (tertile 2), and high (highest tertile). Healthy lifestyle factors included no/moderate alcohol consumption, no smoking, physical activity, and a healthy diet. Participants were categorized into three groups according to their number of healt

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9052486 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature