Genetic and phenotypic analysis of the causal relationship between aging and COVID-19.

ABSTRACT:

Background

Epidemiological studies revealed that the elderly and those with comorbidities are most affected by COVID-19, but it is important to investigate shared genetic mechanisms between COVID-19 risk and aging.

Methods

We conducted a multi-instrument Mendelian Randomization analysis of multiple lifespan-related traits and COVID-19. Aging clock models were applied to the subjects with different COVID-19 conditions in the UK-Biobank cohort. We performed a bivariate genomic scan for age-related COVID-19 and Mendelian Randomization analysis of 389 immune cell traits to investigate their effect on lifespan and COVID-19 risk.

Results

We show that the genetic variation that supports longer life is significantly associated with the lower risk of COVID-19 infection and hos

SUBMITTER: Ying K 

PROVIDER: S-EPMC9053191 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature