Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons.

ABSTRACT: Relative Biological Effectiveness (RBE), the ratio of doses between radiation modalities to produce the same biological endpoint, is a controversial and important topic in proton therapy. A number of phenomenological models incorporate variable RBE as a function of Linear Energy Transfer (LET), though a lack of mechanistic description limits their applicability. In this work we take a different approach, using a track structure model employing fundamental physics and chemistry to make predictions of proton and photon induced DNA damage, the first step in the mechanism of radiation-induced cell death. We apply this model to a proton therapy clinical case showing, for the first time, predictions of DNA damage on a patient treatment plan. Our model predictions are for an idealised cell and ar

SUBMITTER: Henthorn NT 

PROVIDER: S-EPMC9061037 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature