Higher subcutaneous adipose tissue radiodensity is associated with increased mortality in patients with cirrhosis.

ABSTRACT:

Background & aims

Association between sarcopenia and mortality in cirrhosis is well recognised; however, little is known about the clinical implications of adipose tissue radiodensity, indicative of biological features. This study aimed to determine an association between high subcutaneous adipose tissue (SAT) radiodensity and survival, compare the prevalence of high SAT radiodensity between healthy population and patients with cirrhosis, and identify an association between computed tomography (CT)-measured SAT radiodensity and histological characteristics.

Methods

Adult patients with cirrhosis (n = 786) and healthy donors (n = 129) with CT images taken as part of the liver transplant (LT) assessment were included. Abdominal SAT biopsies (1-2 g) were harvested from the incis

SUBMITTER: Ebadi M 

PROVIDER: S-EPMC9117882 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature