Dynamic functional connectivity patterns associated with dementia risk.

ABSTRACT:

Background

This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk.

Methods

DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC.

Results

Associations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-l

SUBMITTER: Dautricourt S 

PROVIDER: S-EPMC9128270 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature