Use of Thiazide Diuretics and Risk of All Types of Skin Cancers: An Updated Systematic Review and Meta-Analysis.

ABSTRACT:

Background

The use of thiazide diuretics is associated with skin cancer risk; however, whether this applies to all skin cancer types is unclear.

Methods

In this meta-analysis, we searched multiple electronic databases and gray literature up to 10 April 2022, with no language restrictions, to identify relevant randomized controlled trials (RCTs) and non-randomized studies (cohort, case-control) that investigated the association between thiazide diuretics and skin cancer. The primary outcomes of interest were malignant melanoma and non-melanoma skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC]). Secondary outcomes included other skin cancers (lip cancer, Merkel cell carcinoma, malignant adnexal skin tumors, oral cavity cancer, and precursors of skin cancer

SUBMITTER: Nochaiwong S 

PROVIDER: S-EPMC9140049 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature