Feasibility of ¹⁸F-Fluorocholine PET for Evaluating Skeletal Muscle Atrophy in a Starved Rat Model.

ABSTRACT: Imaging techniques for diagnosing muscle atrophy and sarcopenia remain insufficient, although various advanced diagnostic methods have been established. We explored the feasibility of ¹⁸F-fluorocholine (¹⁸F-FCH) positron emission tomography/computed tomography (PET/CT) for evaluating skeletal muscle atrophy, as an imaging technique that tracks choline level changes in muscles. Cell uptake in L6 cells by ¹⁸F-FCH was performed in a complete medium containing serum (untreated group, UN) and a serum-free medium (starved group, ST). Small-animal-dedicated PET/CT imaging with ¹⁸F-FCH was examined in in-vivo models with rats that were starved for 2 days to cause muscle atrophy. After the hind limbs were dissected, starvation-induced in-vivo models were

SUBMITTER: Park SM 

PROVIDER: S-EPMC9141294 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature