Feasibility and Optimal Time Point of [⁶⁸Ga]Gallium-labeled Prostate-specific Membrane Antigen Ligand Positron Emission Tomography Imaging in Patients Undergoing Cytoreductive Surgery After Systemic Therapy for Primary Oligometastatic Prostate Cancer: Implications for Patient Selection and Extent of Surgery.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA) targeted molecular imaging using positron emission tomography (PET) has significantly improved the diagnosis and treatment of prostate cancer (PCA).

Objective

To assess the feasibility and compare the diagnostic accuracy of [⁶⁸Ga]Ga-PSMA-11 PET images taken at baseline, before the initiation of systemic treatment and preoperative images, using histopathology after cytoreductive surgery as reference.

Design setting and participants

We identified 20 patients in our prospectively maintained database with primary oligometastatic PCA who underwent cytoreductive radical prostatectomy and superextended pelvic lymph node dissection after systemic therapy, who had baseline and preoperative [⁶⁸Ga]Ga-PSMA

SUBMITTER: Huebner N 

PROVIDER: S-EPMC9142741 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature