PET Imaging of Acidic Tumor Environment With 89Zr-labeled pHLIP Probes.
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ABSTRACT:
SUBMITTER: Bauer D
PROVIDER: S-EPMC9160799 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
PET Imaging of Acidic Tumor Environment With <sup>89</sup>Zr-labeled pHLIP Probes.
Bauer David D Visca Hannah H Weerakkody Anuradha A Carter Lukas M LM Samuels Zachary Z Kaminsky Spencer S Andreev Oleg A OA Reshetnyak Yana K YK Lewis Jason S JS
Frontiers in oncology 20220519
Acidosis of the tumor microenvironment is a hallmark of tumor progression and has emerged as an essential biomarker for cancer diagnosis, prognosis, and evaluation of treatment response. A tool for quantitatively visualizing the acidic tumor environment could significantly advance our understanding of the behavior of aggressive tumors, improving patient management and outcomes. <sup>89</sup>Zr-labeled pH-low insertion peptides (pHLIP) are a class of radiopharmaceutical imaging probes for the <i> ...[more]
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