Tumor-associated macrophages and risk of recurrence in stage III colorectal cancer.

ABSTRACT: Tumor-associated macrophages (TAMs) have a unique favorable effect on the prognosis of colorectal cancer (CRC), although their association with stage-specific outcomes remains unclear. We assessed the densities of CD68⁺ and CD163⁺ TAMs at the invasive front of resected CRC stage III CRC from 236 patients, 165 of whom received post-surgical FOLFOX treatment, and their relationship with disease-free survival (DFS). Associations between macrophage mRNAs and clinical outcome were investigated in silico in 59 stage III CRC and FOLFOX-treated patients from The Cancer Genome Atlas (TCGA). Biological interactions of SW480 and HT29 cells and macrophages with FOLFOX were tested in co-culture models. Low TAM densities were associated with shorter DFS among patients receiving FOL

SUBMITTER: Cavalleri T 

PROVIDER: S-EPMC9161313 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature