Decade-long leukaemia remissions with persistence of CD4⁺ CAR T cells.

ABSTRACT: The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers^1-7. However, little is known about the long-term potential and clonal stability of the infused cells. Here we studied long-lasting CD19-redirected chimeric antigen receptor (CAR) T cells in two patients with chronic lymphocytic leukaemia^1-4 who achieved a complete remission in 2010. CAR T cells remained detectable more than ten years after infusion, with sustained remission in both patients. Notably, a highly activated CD4⁺ population emerged in both patients, dominating the CAR T cell population at the later time points. This transition was reflected in the stabilization of the clonal make-up of CAR T cells with a repertoir

SUBMITTER: Melenhorst JJ 

PROVIDER: S-EPMC9166916 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature