CD4⁺ and CD8⁺ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment.

ABSTRACT: SARS-CoV-2 infection induces the generation of virus-specific CD4⁺ and CD8⁺ effector and memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during infection is not well understood. Following infection of C57BL/6 mice, SARS-CoV-2-specific CD4⁺ and CD8⁺ T cells are recruited to the respiratory tract, and a vast proportion secrete the cytotoxic molecule granzyme B. Using depleting antibodies, we found that T cells within the lungs play a minimal role in viral control, and viral clearance occurs in the absence of both CD4⁺ and CD8⁺ T cells through 28 days postinfection. In the nasal compartment, depletion of both CD4⁺ and CD8⁺ T cells, but not individually, results in persistent,

SUBMITTER: Kar M 

PROVIDER: S-EPMC11343035 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature