Hypocomplementemia in primary Sjogren's syndrome: association with serological, clinical features, and outcome.

ABSTRACT:

Objective

The aim of the present study was to assess the clinical characteristic of hypocomplementemia (HC) in primary Sjogren's syndrome (pSS), and to address possible risk factors and the prognosis associated with HC in pSS patients.

Methods

pSS patients with HC in Hebei General Hospital from September 2016 to March 2019 were retrospectively analyzed and compared to those with normocomplementemia (NC). Logistic regression analysis was used to detect risk factors.

Results

Of the 333 patients with pSS, 84 patients (25.23%) were presented with HC at diagnosis. The presence of hyper-IgG and anti-Ro52 antibodies was significantly more common in patients with HC. In addition to systemic involvement, pSS patients with HC had more hematological, renal, and nervous system in

SUBMITTER: Lin W 

PROVIDER: S-EPMC9187545 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature