SLOW: A novel spectral editing method for whole-brain MRSI at ultra high magnetic field.

ABSTRACT:

Purpose

At ultra-high field (UHF), B₁⁺ -inhomogeneities and high specific absorption rate (SAR) of adiabatic slice-selective RF-pulses make spatial resolved spectral-editing extremely challenging with the conventional MEGA-approach. The purpose of the study was to develop a whole-brain resolved spectral-editing MRSI at UHF (UHF, B₀  ≥ 7T) within clinical acceptable measurement-time and minimal chemical-shift-displacement-artifacts (CSDA) allowing for simultaneous GABA/Glx-, 2HG-, and PE-editing on a clinical approved 7T-scanner.

Methods

Slice-selective adiabatic refocusing RF-pulses (2π-SSAP) dominate the SAR to the patient in (semi)LASER based MEGA-editing sequences, causing large CSDA and long measurement times to fulfill SAR requirements,

SUBMITTER: Weng G 

PROVIDER: S-EPMC9212787 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature