A Mutation in Endogenous saRNA miR-23a Influences Granulosa Cells Response to Oxidative Stress.

ABSTRACT: Phenotypes are the result of the interaction between the gene and the environment, so the response of individuals with different genotypes to an environment is variable. Here, we reported that a mutation in miR-23a influences granulosa cells (GCs) response to oxidative stress, a common mechanism of environmental factors affecting female reproduction. We showed that nuclear miR-23a is a pro-apoptotic miRNA in porcine GCs through the activation of the transcription and function of NORHA, a long non-coding RNA (lncRNA) induces GC apoptosis and responses to oxidative stress. Mechanistically, miR-23a acts as an endogenous small activating RNA (saRNA) to alter histone modifications of the NORHA promoter through the direct binding to its core promoter. A C > T mutation was identi

SUBMITTER: Wang S 

PROVIDER: S-EPMC9219974 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature