Dataset Information

Optical coherence tomography angiography in Alzheimer's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

To assess the association between optical coherence tomography angiography (OCTA) retinal measurements and Alzheimer's disease (AD).

Methods

We searched MEDLINE and EMBASE from inception up to October 28th, 2020 for studies assessing the association between OCTA retinal measurements and AD. Estimates from eligible studies were meta-analysed and pooled standardized mean differences (SMDs) between AD patients and healthy participants with corresponding 95% confidence intervals (95% CI) were calculated, using the Hartung-Knapp/Sidik-Jonkman random-effects method. In addition, we quantified the minimum strength on the risk ratio scale (E value) required for an unmeasured confounder to nullify these associations.

Results

Ten eligible studies for our systematic review were identified through our search strategy. The pooled SMD between the retinal vessel density of AD patients and healthy participants in the whole superficial vascular plexus (SVP), parafoveal SVP and foveal avascular zone (FAZ) was -0.41 (95% CI: -0.69 to -0.13, p value = 0.01, I² = 15%, seven studies), -0.51 (95% CI: -0.84 to -0.18, p value = 0.01, I² = 40%, six studies), and 0.87 (95% CI: -0.03 to 1.76, p value = 0.05, I² = 91%, seven studies), respectively. An unmeasured confounder would need to be associated with a 2.26-, 2.56- and 3.82-fold increase in the risk of AD and OCTA retinal measurements, in order for the pooled SMD estimate of vessel density in whole SVP, parafoveal SVP and FAZ, respectively, to be nullified.

Conclusions

In our study, whole and parafoveal SVP vessel density were inversely associated with AD. However, prospective longitudinal studies with larger sample sizes are needed to furtherly assess these associations.

SUBMITTER: Katsimpris A

PROVIDER: S-EPMC9232568 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Optical coherence tomography angiography in Alzheimer's disease: a systematic review and meta-analysis.

Katsimpris Andreas A Karamaounas Aristotelis A Sideri Anna Maria AM Katsimpris John J Georgalas Ilias I Petrou Petros P

Eye (London, England) 20210630 7

<h4>Background</h4>To assess the association between optical coherence tomography angiography (OCTA) retinal measurements and Alzheimer's disease (AD).<h4>Methods</h4>We searched MEDLINE and EMBASE from inception up to October 28th, 2020 for studies assessing the association between OCTA retinal measurements and AD. Estimates from eligible studies were meta-analysed and pooled standardized mean differences (SMDs) between AD patients and healthy participants with corresponding 95% confidence inte ...[more]

PMID: 34193983

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Dataset Information

Optical coherence tomography angiography in Alzheimer's disease: a systematic review and meta-analysis.

Background

Methods

Results

Conclusions

Publications

Optical coherence tomography angiography in Alzheimer's disease: a systematic review and meta-analysis.

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