The plant epitranscriptome: revisiting pseudouridine and 2'-O-methyl RNA modifications.

ABSTRACT: There is growing evidence that post-transcriptional RNA modifications are highly dynamic and can be used to improve crop production. Although more than 172 unique types of RNA modifications have been identified throughout the kingdom of life, we are yet to leverage upon the understanding to optimize RNA modifications in crops to improve productivity. The contributions of internal mRNA modifications such as N6-methyladenosine (m⁶ A) and 5-methylcytosine (m⁵ C) methylations to embryonic development, root development, leaf morphogenesis, flowering, fruit ripening and stress response are sufficiently known, but the roles of the two most abundant RNA modifications, pseudouridine (Ψ) and 2'-O-methylation (Nm), in the cell remain unclear due to insufficient advances in high-

SUBMITTER: Ramakrishnan M 

PROVIDER: S-EPMC9241379 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature