Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction.

ABSTRACT:

Importance

Extracellular matrix proteins and enzymes involved in degradation have been found to be associated with tissue fibrosis and ureteropelvic junction obstruction (UPJO). In this study we developed a promising urinary biomarker model which can identify reduced renal function in UPJ obstruction patients. This can potentially serve as a non-invasive way to enhance surgical decision making for patients and urologists.

Objective

We sought to develop a predictive model to identify UPJO patients at risk for reduced renal function.

Design

Prospective cohort study.

Setting

Pre-operative urine samples were collected in a prospectively enrolled UPJO biomarker registry at our institution. Urinary MMP-2, MMP-7, TIMP-2, and NGAL were measured as well as clinical char

SUBMITTER: Wang HS 

PROVIDER: S-EPMC9282603 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature