Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization.

ABSTRACT:

Methods

Based on the latest genome-wide association study summary data, bidirectional two-sample Mendelian randomization (MR) was employed to detect the causal relationship and effect direction between TSH, fT4, and CRP. Furthermore, in view of obesity being an important risk factor of CVD, obesity trait waist-hip ratio (WHR) and body mass index (BMI) were treated as the research objects in MR analyses for exploring the causal effects of TSH and fT4 on them, respectively.

Results

Genetically increased CRP was associated with increased TSH (β = -0.02, P = 0.011) and with increased fT4 (β = 0.043, P = 0.001), respectively, but there was no evidence that TSH or fT4 could affect CRP. In further analyses, genetically increased TSH was associated with d

SUBMITTER: Li T 

PROVIDER: S-EPMC9392607 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature