Exposure of the heart and cardiac valves in women irradiated for breast cancer 1970-2009.

ABSTRACT:

Purpose

To describe cardiac exposure from breast cancer radiotherapy regimens used during 1970-2009 for the development of dose-response relationships and to consider the associated radiation-risks using existing dose-response relationships.

Material and methods

Radiotherapy charts for 771 women in the Netherlands selected for case control studies of heart disease after breast cancer radiotherapy were used to reconstruct 44 regimens on a typical CT-dataset. Doses were estimated for the whole heart (WH), left ventricle (LV) and cardiac valves.

Results

For breast/chest wall radiotherapy average WH doses decreased during 1970-2009. For internal mammary chain (IMC) radiotherapy WH doses were highest during the 1980s and 1990s when direct anterior fields were used and redu

SUBMITTER: Duane FK 

PROVIDER: S-EPMC9399376 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature