Dataset Information

Association of Barrett's esophagus with Helicobacter pylori infection: a meta-analysis.

ABSTRACT:

Background and aims

Barrett's esophagus (BE) is the only recognized precursor for esophageal adenocarcinoma. Helicobacter pylori (H. pylori) infection is a major contributing factor towards upper gastrointestinal diseases, but its relationship with BE remains controversial. Some previous studies suggested that H. pylori infection negatively correlated with BE, while others did not. This may be attributed to the difference in the selection of control groups among studies. The present meta-analysis aims to clarify their association by combining all available data from well-designed studies.

Methods

The PubMed, EMBASE, and Cochrane Library databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effects model. Heterogeneity was evaluated using the Cochran's Q test and I ² statistics. Meta-regression, subgroup, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity.

Results

Twenty-four studies with 1,354,369 participants were included. Meta-analysis found that patients with BE had a significantly lower prevalence of H. pylori infection than those without (OR = 0.53, 95% CI = 0.45-0.64; p < 0.001). The heterogeneity was statistically significant (I² = 79%; p < 0.001). Meta-regression, subgroup, and leave-one-out sensitivity analyses did not find any source of heterogeneity. Meta-analysis of 7 studies demonstrated that CagA-positive H. pylori infection inversely correlated with BE (OR = 0.25, 95% CI = 0.15-0.44; p = 0.000), but not CagA-negative H. pylori infection (OR = 1.22, 95% CI = 0.90-1.67; p = 0.206). Meta-analysis of 4 studies also demonstrated that H. pylori infection inversely correlated with LSBE (OR = 0.39, 95% CI = 0.18-0.86; p = 0.019), but not SSBE (OR = 0.73, 95% CI = 0.30-1.77; p = 0.484).

Conclusion

H. pylori infection negatively correlates with BE. More experimental studies should be necessary to elucidate the potential mechanisms in future.

SUBMITTER: Ma S

PROVIDER: S-EPMC9403448 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Association of Barrett's esophagus with <i>Helicobacter pylori</i> infection: a meta-analysis.

Ma Shaoze S Guo Xiaozhong X Wang Chunmei C Yin Yue Y Xu Guangqin G Chen Hongxin H Qi Xingshun X

Therapeutic advances in chronic disease 20220822

<h4>Background and aims</h4>Barrett's esophagus (BE) is the only recognized precursor for esophageal adenocarcinoma. <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is a major contributing factor towards upper gastrointestinal diseases, but its relationship with BE remains controversial. Some previous studies suggested that <i>H. pylori</i> infection negatively correlated with BE, while others did not. This may be attributed to the difference in the selection of control groups among stud ...[more]

PMID: 36034104

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