CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques.

ABSTRACT: Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recently, robust vaccine prevention of severe disease with SARS-CoV-2 variants that largely escape NAb responses has been reported, suggesting a role for other immune parameters for virologic control. However, direct data demonstrating a role of CD8⁺ T cells in vaccine protection have not yet been reported. In this study, we show that vaccine-elicited CD8⁺ T cells contribute substantially to virologic control after SARS-CoV-2 challenge in rhesus macaques. We vaccinated 30 macaques with a single immunization of the adenovirus vector-based vaccine Ad26.COV2.S or sham and then challenge

SUBMITTER: Liu J 

PROVIDER: S-EPMC9407944 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature