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Lactate metabolism in human health and disease.


ABSTRACT: The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao's research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction. Therefore, a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research. This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes, as well as a comprehensive overview of the effects of lactylation in various diseases, particularly inflammation and cancer.

SUBMITTER: Li X 

PROVIDER: S-EPMC9434547 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Lactate metabolism in human health and disease.

Li Xiaolu X   Yang Yanyan Y   Zhang Bei B   Lin Xiaotong X   Fu Xiuxiu X   An Yi Y   Zou Yulin Y   Wang Jian-Xun JX   Wang Zhibin Z   Yu Tao T  

Signal transduction and targeted therapy 20220901 1


The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao's research group in 2019. Subsequent studies confirmed  ...[more]

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