Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC9434547 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Li Xiaolu X Yang Yanyan Y Zhang Bei B Lin Xiaotong X Fu Xiuxiu X An Yi Y Zou Yulin Y Wang Jian-Xun JX Wang Zhibin Z Yu Tao T
Signal transduction and targeted therapy 20220901 1
The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao's research group in 2019. Subsequent studies confirmed ...[more]