Neutrophil extracellular traps facilitate cancer metastasis: cellular mechanisms and therapeutic strategies.

ABSTRACT:

Background

The formation of neutrophil extracellular traps (NETs) was initially discovered as a novel immune response against pathogens. Recent studies have also suggested that NETs play an important role in tumor progression. This review summarizes the cellular mechanisms by which NETs promote distant metastasis and discusses the possible clinical applications targeting NETs.

Method

The relevant literature from PubMed and Google Scholar (2001-2021) have been reviewed for this article.

Results

The presence of NETs has been detected in various primary tumors and metastatic sites. NET-associated interactions have been observed throughout the different stages of metastasis, including initial tumor cell detachment, intravasation and extravasation, the survival of circulat

SUBMITTER: Hu W 

PROVIDER: S-EPMC9436160 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature