Ontology highlight
ABSTRACT:
SUBMITTER: Woodring T
PROVIDER: S-EPMC9436750 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Woodring Therese T Dewey Colin N CN Santos Dias Lucas Dos LD He Xin X Dobson Hannah E HE Wüthrich Marcel M Klein Bruce B
iScience 20220813 9
Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory cells that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific CD4<sup>+</sup>T cells recalled to lungs of mice that received a protective or nonprotective subunit vaccine followed by challenge with a fungal pathogen. We unexpectedly found populations specific to protection that expressed a strong type I interferon response signature, ...[more]