Cycling and activated CD8⁺ T lymphocytes and their association with disease severity in influenza patients.

ABSTRACT:

Background

T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity.

Methods

In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry.

Results

The numbers of cycling (Ki67⁺) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO⁺) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation durin

SUBMITTER: Liu S 

PROVIDER: S-EPMC9441835 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature