Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations.

ABSTRACT: Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val¹⁵⁸Met and brain-derived neurotrophic factor (BDNF) Val⁶⁶Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and

SUBMITTER: Simola J 

PROVIDER: S-EPMC9460523 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature