Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen Candida albicans.

ABSTRACT: The human gut microbiota protects the host from invading pathogens and the overgrowth of indigenous opportunistic species via a process called colonization resistance. Here, we investigated the antagonistic activity of human gut bacteria towards Candida albicans, an opportunistic fungal pathogen that can cause severe infections in susceptible individuals. Coculture batch incubations of C. albicans in the presence of faecal microbiota from six healthy individuals revealed varying levels of inhibitory activity against C. albicans. 16S rRNA gene amplicon profiling of these faecal coculture bacterial communities showed that the Bifidobacteriaceae family, and Bifidobacterium adolescentis in particular, were most correlated with antagonistic activity against C. albicans. Follow-up mechanistic st

SUBMITTER: Ricci L 

PROVIDER: S-EPMC9486989 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature