Metabolic Engineering of Escherichia coli for High-Level Production of Salicin.
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SUBMITTER: Zhang M
PROVIDER: S-EPMC9494424 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Metabolic Engineering of <i>Escherichia coli</i> for High-Level Production of Salicin.
Zhang Mengqi M Liu Chang C Xi Daoyi D Bi Huiping H Cui Zhanzhao Z Zhuang Yibin Y Yin Hua H Liu Tao T
ACS omega 20220908 37
Salicin is a notable phenolic glycoside derived from plants including <i>Salix</i> and <i>Populus</i> genus and has multiple biological activities such as anti-inflammatory and antiarthritic, anticancer, and antiaging effects. In this work, we engineered production of salicin from cheap renewable carbon resources in <i>Escherichia coli</i> (<i>E. coli</i>) by extending the shikimate pathway. We first investigated enzymes synthesizing salicylate from chorismate. Subsequently, carboxylic acid redu ...[more]
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