Regulation of T-independent B-cell responses by microRNA-146a.
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ABSTRACT:
SUBMITTER: King JK
PROVIDER: S-EPMC9511149 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Regulation of T-independent B-cell responses by microRNA-146a.
King Jennifer K JK Tran Tiffany M TM Paing May H MH Yin Yuxin Y Jaiswal Amit K AK Tso Ching-Hsuan CH Roy Koushik K Casero David D Rao Dinesh S DS
Frontiers in immunology 20220912
The microRNA, miR-146a, is a negative feedback regulator of the central immune transcription factor, nuclear factor kappa B (NFkB). MiR-146a plays important roles in the immune system, and miR-146a deficient mice show a complex phenotype with features of chronic inflammation and autoimmune disease. In this study, we examined the role of miR-146a in extrafollicular B-cell responses, finding that miR-146a suppresses cellular responses <i>in vivo</i> and <i>in vitro</i>. Gene expression profiling r ...[more]
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