Chromosomal coharboring of bla_IMP-60 and mcr-9 in Enterobacter asburiae isolated from a Japanese woman with empyema: a case report.

ABSTRACT:

Background

Polymyxin E (colistin) is a last-resort antibiotic to treat infections caused by carbapenemase-producing Enterobacteriaceae (CPE). However, reports of CPEs resistant to colistin have been increasing, and the mcr genes are emerging as resistance mechanisms. Among them, plasmid-mediate mcr-9 is known to be associated with colistin resistance, whereas reports on chromosomal mcr-9 and its association with colistin resistance in humans are few.

Case presentation

We identified Enterobacter asburiae harboring mcr-9 and bla_IMP-60 in the pleural fluid of a patient with empyema. The long-read sequencing technique revealed that these genes were located on its chromosome. Despite the lack of exposure to colistin, the organism showed microcolonies in the inhibition

SUBMITTER: Miyazato Y 

PROVIDER: S-EPMC9523918 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature